Understanding Thyroid Storm: Causes, Symptoms, Treatment, and Prognosis

Understanding Thyroid Storm: Causes, Symptoms, Treatment, and Prognosis

Understanding thyroid storm
©️ Marcelo Leal on Unsplash

The thyroid, a small butterfly-shaped gland located in the neck, plays a vital role in regulating your body’s metabolism. Normally, it produces just the right amount of hormones (T3 and T4) to keep your body functioning optimally. However, in some cases, the thyroid can go into overdrive, leading to a potentially life-threatening condition known as a “thyroid storm.” 

In this article, we will delve into the details of the thyroid storm, including its causes, symptoms, diagnosis, treatment, prognosis, and prevention.

What are some causes of thyroid storm?

A thyroid storm is typically triggered by underlying hyperthyroidism, a condition often caused by Graves’ disease, toxic multinodular goiter, or thyroiditis. Several factors can trigger or exacerbate thyroid storm, including:

  • Non-compliance with medication: Failing to take prescribed medications for hyperthyroidism.
  • Infection or illness: Severe infections, such as pneumonia, upper respiratory tract infections, or urinary tract infections, can stress the body and trigger thyroid storm in susceptible individuals.
  • Surgery or trauma: Certain medical procedures, such as surgical operations on the thyroid or surgeries for other health conditions may stimulate the release of excess thyroid hormones. Physical trauma or damage to the thyroid can also trigger a spike in the release of thyroid hormones into the bloodstream.
  • Pregnancy and childbirth: Hormonal changes during pregnancy or after childbirth can exacerbate hyperthyroidism.
  • Certain medications: Some medications, like iodine-containing drugs or contrast agents used in imaging procedures, tend to increase thyroid hormone release and can therefore worsen hyperthyroidism and contribute to a thyroid storm.

What are some symptoms of thyroid storm?

Like myxedema coma, a thyroid storm is also a medical emergency. The symptoms of thyroid storm are often dramatic and require immediate medical attention. It is also important to note that these symptoms tend to mimic other medical emergencies.  This means that thyroid storm can only be confirmed by a diagnosis based on a comprehensive medical examination, and not solely based on symptoms. Common symptoms include:

  • High fever (often exceeding 104°F or 40°C)
  • Rapid and irregular heartbeat (tachycardia)
  • High blood pressure
  • Profuse sweating
  • Extreme agitation and confusion
  • Nausea, vomiting, and diarrhea
  • Tremors and muscle weakness
  • Jaundice (yellowing of the skin and eyes)
  • Difficulty in breathing
  • Delirium or loss of consciousness (in severe cases)

How is thyroid storm diagnosed?

Diagnosing a thyroid storm is crucial, as the condition can be mistaken for other medical emergencies like sepsis. Misdiagnosing thyroid storm is actually not far-fetched owing to the overlap of symptoms of hyperthyroidism and thyroid storm with those of other health conditions. 

Diagnosing a thyroid storm, therefore, requires a combination of clinical assessment of symptoms and laboratory tests. A physical examination to assess vital signs, including heart rate, blood pressure, and temperature will be performed by the doctor. Blood tests to measure thyroid hormone levels (T3 and T4) and thyroid-stimulating hormone (TSH) are also required for confirmation. Abnormally high levels of T4 with abnormally low levels of TSH tend to be indicative of thyroid storm. 

Additionally, other tests such as liver function tests (LFTs) and kidney function tests (KFTs) may be performed to assess organ function and identify any underlying triggers. Imaging studies (such as thyroid scans) are also helpful in the assessment of the size and general condition of the thyroid gland.

How is thyroid storm treated?

Individuals with thyroid storm require immediate hospitalization, usually in an intensive care unit (ICU), and treatment. The goals of treatment are to inhibit thyroid hormone production, stabilize vital signs, and address precipitating factors (which are typically the underlying causes of hyperthyroidism). Treatment options include:

  • Antithyroid drugs: Drugs such as propylthiouracil and methimazole are used to block the production of thyroid hormones.
  • Beta-blockers: Medications like propranolol can help control heart rate and alleviate the symptoms of hyperthyroidism.
  • Iodine therapy: High-dose iodine, usually in the form of saturated solution of potassium iodide (SSKI) or Lugol’s solution, may be given to inhibit thyroid hormone release. It might seem a bit counterintuitive because iodine is used in thyroid hormone production, but these solutions are able to temporarily block the release of thyroid hormones from the overactive thyroid gland by saturating the thyroid with non-reactive iodine. This is not a long-term treatment approach as its goal is to merely reduce the symptoms of hyperthyroidism.
  • Supportive care: Patients often need intravenous (IV) fluids to maintain hydration and electrolyte balance, and cooling measures for fever management. Hyperthermia can be life-threatening, so cooling measures like cooling blankets or ice packs may be used to lower body temperature.

Prognosis and Long-Term Management

With prompt and appropriate treatment, many individuals with thyroid storm can recover. Patients may begin to feel better as early as within 24 hours of receiving treatment. However, it’s essential to manage the underlying hyperthyroidism to prevent future episodes. Long-term management may involve ongoing medication or radioactive iodine therapy. In severe cases, where conservative treatment fails, or if the patient is unresponsive, more aggressive interventions like plasmapheresis or thyroidectomy (surgical removal of the thyroid gland) may be considered. 

While treatment options like thyroidectomy and radioactive iodine therapy can treat hyperthyroidism permanently, this is typically followed by the development of hypothyroidism and hence the need for lifelong intake of thyroid hormone replacement medications. This may seem overwhelming, but the ThyForLife app is here to serve as your digital companion to help make everything a little easier. The app helps you stay on top of your thyroid health by making it possible for you to log your bloodwork, monitor your symptoms, and track your medication intake, among many other exciting features.

Can thyroid storm be prevented?

The simple answer is yes. Keep in mind that thyroid storm is a rare medical condition that results from untreated hyperthyroidism. If hyperthyroidism is properly treated and the individual responds well to treatment, the condition cannot transform into a severe life-threatening medical emergency known as a thyroid storm. If you or someone you know experiences symptoms of thyroid storm, do not hesitate to seek emergency medical care in order to prevent potentially fatal complications.

Key Takeaways:

  • A thyroid storm, also known as a thyrotoxic crisis, is a rare but life-threatening medical emergency and occurs as a severe manifestation of hyperthyroidism.
  • Blood tests, physical examinations and imaging studies are the main diagnostic approaches for thyroid storm.
  • The primary goal of treating a thyroid storm is to stabilize the patient and control excessive thyroid hormone production.
  • Treating the underlying hypothyroidism is crucial in the management of thyroid storm.
  • Early intervention and proper medical care can significantly improve the prognosis and prevent life-threatening complications associated with this condition.
  • Being aware of the symptoms and risk factors is crucial, especially for individuals with hyperthyroidism.
  • If you suspect you or someone you know may be experiencing a thyroid storm, seek immediate medical attention.


At ThyForLife, we do our utmost to provide accurate information. For detailed medical information regarding diagnosis, treatment, and general practices please consult your healthcare professional. Always listen to the advice of your healthcare provider.
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